Thermo Fisher Scientific PPARD Monoclonal Antibody (OTI4D10), TrueMAB
인간 PPARD 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 IHC(P)에서 검증됨. 1 mg/mL 농도의 액상 형태이며, PBS/BSA/glycerol buffer에 보관. -20°C에서 보관하며, 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4D10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–244 of human PPARD produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer.
This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells, and can be repressed by the tumor suppressor protein APC related to the APC/beta-catenin signaling pathway. Knockout studies in mice suggested roles in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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