Thermo Fisher Scientific CD101 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

CD101, also known as V7 antigen, is a member of the immunoglobulin superfamily. It forms a disulfide-linked homodimer of unknown function and is expressed on monocytes, granulocytes, and dendritic cells (Langerhans-like cells expressing HLA-DR, CD1a, CD1c).
Expression on T lymphocytes is important for cell activation. CD101⁺ CD28⁺ cells respond strongly to CD28 signaling, and in combination with anti-CD28 or suboptimal levels of anti-CD3, anti-CD101 can enhance proliferation, suggesting an activating role.
The monoclonal antibody BB27 has been shown to inhibit T cell reactivity in allogeneic and antigen-specific mixed DC–T cell cultures. Mouse CD101 is expressed on a subpopulation of regulatory T cells (CD4⁺, CD25⁺, Foxp3⁺) with high suppressor activity.
Human PBMCs show CD101 expression on about 30% of Foxp3⁺ cells, though studies have not confirmed higher suppressor activity in this population.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.