Thermo Fisher Scientific C4BPA Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human C4BPA. Recombinant protein control fragment (Product #RP-95397). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:C4BPA,uniProtId:P04003-1,ncbiNodeId:9606,antigenRange:454-592,antigenLength:597,antigenImageFileName:PA5-81906_C4BPA_P04003-1_Rabbit.svg,antigenImageFileNamePDP:PA5-81906_C4BPA_P04003-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.12 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2789067

Product Specific Information

Immunogen sequence: CDKGYILVGQ AKLSCSYSHW SAPAPQCKAL CRKPELVNGR LSVDKDQYVE PENVTIQCDS GYGVVGPQSI TCSGNRTWYP EVPKCEWETP EGCEQVLTGK RLMQCLPNPE DVKMALEVYK LSLEIEQLEL QRDSARQST

Target Information

There are 3 variants of Complement component 4 binding protein (C4bp), which is composed of alpha and beta chains. The predominant form is a 570 kDa complex of 7 alpha chains and 1 beta chain. The other complexes formed are a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. C4bp regulates the activation of the classical complement pathway. It is a cofactor to the C3b/C4b inactivator, crucial to the proteolytic cleavage of C4b and important in cleavage of C3b. C4bp also regulates the C4bC2a complex (C3 convertase), accelerating its degradation by dissociating the complement fragment C2a. Both the C4bp alpha and beta chains interact with anticoagulant protein S and C4bp alpha binds protein S. C4bp is expressed in the blood serum.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.