Thermo Fisher Scientific PBR Polyclonal Antibody
PBR 단백항체로 인간 및 랫트 시료에 반응하며 WB, IHC, ELISA, IP 등 다양한 분석에 적합합니다. 합성 펩타이드 면역원으로 제작된 Rabbit Polyclonal Antibody이며, 고순도 친화 크로마토그래피 정제 및 안정적인 액상 형태로 제공됩니다.
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Thermo Fisher Scientific PBR Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to unique amino acid sequence on 18 kDa mitochondrial benzodiazepine receptor protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an essential component of the steroidogenic machinery, mediating cholesterol delivery to the inner mitochondrial membrane upon ligand activation. PBR consists of three subunits: an isoquinoline binding site, a voltage-dependent anion channel, and an adenine nucleotide carrier. It is conserved from bacteria to humans, widely expressed in peripheral organs, and mainly localized in glial cells within the brain. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits Leydig cell steroidogenesis by destabilizing PBR mRNA, thereby suppressing PBR expression, cholesterol transport, and steroid formation. The cytoplasmic protein PRAX-1 (Peripheral Benzodiazepine Receptor-Associated Protein 1) specifically interacts with PBR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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