Thermo Fisher Scientific West Nile Virus Envelope (Domain III) (lineage 1, strain NY99) Monoclonal Antibody (03)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:1,000–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for West Nile Virus (WNV) (lineage 1, strain NY99) E/Envelope (Domain III).

Target Information

West Nile Virus (WNV) is a member of the Flaviviridae family, a plus-stranded virus group that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus.
WNV was first isolated in 1937 in the West Nile region of Uganda and has since become prevalent in Africa, Asia, and Europe. It has spread across the United States with cases observed in every continental state.

Virus particles consist of a dense core composed of the core/capsid protein encapsulating the RNA genome, surrounded by a membrane envelope embedded with envelope and matrix proteins that play a major role in WNV entry into target cells. The viral core protein is thought to contribute to WNV-associated inflammation via apoptosis induced through the caspase-9 pathway, as delivery of the core gene into mouse brain and skeletal muscle resulted in cell death and inflammation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.