Thermo Fisher Scientific GP130 (extracellular) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:400
• View 1 publication

Flow Cytometry (Flow)

• Tested Dilution: –
• View 1 publication

Product Specifications

Product Specific Information

Product is shipped at room temperature as a lyophilized powder and should be stored at -20°C upon receipt.
Reconstitution: add 50 µL of deionized water.

Target Information

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM).
This protein functions as a part of the cytokine receptor complex, and its activation depends on cytokine binding to their receptors.
vIL6, encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the IL6 receptor (IL6R) and directly activate this protein.
Knockout studies in mice suggest a critical role in regulating myocyte apoptosis.
Alternatively spliced transcript variants encoding distinct isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.