Thermo Fisher Scientific FGF Receptor-alpha Monoclonal Antibody (M1C4)
FGF Receptor-alpha 단백질을 인식하는 mouse monoclonal antibody로, WB, IHC, IP에 사용 가능. Human 시료 반응성. Protein A 정제, PBS buffer 보존. 연구용으로 세포 신호전달 및 성장 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunoprecipitation (IP) | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M1C4 |
| Immunogen | Recombinant human ectodomain of FGFr1 alpha expressed in E. coli beginning with pro23; antigen contained NH2-terminal gly-ser-pro-gly-ile and COOH-terminal glu-phe sequences. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family, which includes four membrane-spanning tyrosine kinases (FGFR1–4) acting as high-affinity receptors for 17 growth factors (FGF1–17).
The FGF receptor family plays critical roles in mesoderm induction and patterning, cell growth and migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, generating multiple variants expressed differently during embryonic development and in adults.
Mutations or defects in FGFR1 are linked to various diseases, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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