Thermo Fisher Scientific FPR1/2 Monoclonal Antibody (NFPR1)
FPR1/FPR2 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 면역세포염색에 적합합니다. 인간 시료 반응성이 있으며, Protein A로 정제된 액상 형태입니다. 연구용으로만 사용되며 진단용이 아닙니다.
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- 30107-100UG
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NFPR1 |
| Immunogen | His-tagged recombinant FPR1 (human neutrophil N-formyl peptide receptor 1) expressed in and purified from Sf9 cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Formyl peptide receptors (FPR) are G protein-coupled receptors activated by different agonists, including N-formylated peptides originating from bacteria and mitochondria.
In humans, the FPR family includes:
- FPR1: High affinity receptor
- FPR2/ALX: Low affinity receptor (previously known as FPRL1 or ALX)
- FPR3
Human FPR1 plays a key role in:
- Phagocyte chemotaxis
- Superoxide production
- Degranulation
- Directing phagocytes to infection sites
Functional FPR1 expression has been demonstrated in fibroblasts, bone marrow mesenchymal stem cells, A549 lung cells, HEP-G2 hepatoma cells, and various epithelial cells.
FPR2 (Formyl Peptide Receptor 2) is a protein-coding gene associated with Diamond-Blackfan Anemia 2 and Prion Disease. Related pathways include Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.
Gene Ontology (GO) annotations include G protein-coupled receptor activity and N-formyl peptide receptor activity.
An important paralog of this gene is FPR3.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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