Thermo Fisher Scientific FPR1/2 Monoclonal Antibody (NFPR1)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

Immunocytochemistry (ICC/IF)

10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

NFPR1

Immunogen

His-tagged recombinant FPR1 (human neutrophil N-formyl peptide receptor 1) expressed in and purified from Sf9 cells. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:FPR1/FPR2,uniProtId:P21462-1,ncbiNodeId:9606,antigenRange:1-350,antigenLength:350,antigenImageFileName:30107-100UG_FPR1FPR2_P21462-1_House_mouse.svg,antigenImageFileNamePDP:30107-100UG_FPR1FPR2_P21462-1_House_mouse_PDP.jpeg,sortOrder:1},{targetFamily:FPR1/FPR2,uniProtId:P25090-1,ncbiNodeId:9606,antigenRange:1-351,antigenLength:351,antigenImageFileName:30107-100UG_FPR1FPR2_P25090-1_House_mouse.svg,antigenImageFileNamePDP:30107-100UG_FPR1FPR2_P25090-1_House_mouse_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.0 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Formyl peptide receptors (FPR) are G protein-coupled receptors that are activated by different agonists included N- formylated peptides originating from bacteria and mitochondria. In humans, the FPR family includes the high affinity FPR1, the low affinity FPR2/ALX (previously known as FPRL1 or ALX) and FPR3. Human FPR1 is important for phagocyte chemotaxis, superoxide production, and degranulation, and helps direct phagocytes to sites of infection. Functional FPR1expression has been demonstrated on fibroblasts, bone marrow mesenchymal stem cells, A549 lung cells, HEP-G2 hepatoma cells, and on several types of epithelial cells. FPR2 (Formyl Peptide Receptor 2) is a Protein Coding gene. Diseases associated with FPR2 include Diamond-Blackfan Anemia 2 and Prion Disease. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.