Thermo Fisher Scientific PHLPPL Polyclonal Antibody
PHLPPL 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Human 및 Mouse 시료에 반응합니다. Western blot과 Immunoprecipitation에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 신호 조절 및 Akt 경로 연구에 유용합니다.
- 카탈로그번호
- A300661A
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific PHLPPL Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 1275 and the C-terminus (residue 1323) of human PH Domain and Leucine Rich Repeat Protein Phosphatase-like |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on Ser-473 of AKT1, Ser-660 of PRKCB isoform beta-II, and Ser-657 of PRKCA.
Akt regulates the balance between cell survival and apoptosis through a cascade that alters transcription factors controlling pro- and antiapoptotic genes.
Dephosphorylation of Ser-473 of Akt triggers apoptosis and decreases cell proliferation. Also controls phosphorylation of AKT3.
Dephosphorylates STK4 on Thr-387 leading to STK4 activation and apoptosis.
Dephosphorylates RPS6KB1 and regulates cap-dependent translation.
Inhibits cancer cell proliferation and may act as a tumor suppressor.
Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation.
Dephosphorylates RAF1 inhibiting its kinase activity.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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