Thermo Fisher Scientific PHLPPL Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on Ser-473 of AKT1, Ser-660 of PRKCB isoform beta-II, and Ser-657 of PRKCA.
Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters transcription factors controlling pro- and antiapoptotic genes.
Dephosphorylation of Ser-473 of Akt triggers apoptosis and decreases cell proliferation. Also controls phosphorylation of AKT3.
Dephosphorylates STK4 on Thr-387 leading to STK4 activation and apoptosis (PubMed:20513427).
Dephosphorylates RPS6KB1 and regulates cap-dependent translation (PubMed:21986499).
Inhibits cancer cell proliferation and may act as a tumor suppressor.
Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation.
Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606).
[UniProt]

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

제품 이미지

(이미지 파일명: A300-661A-M_PHLPP2_Q6ZVD8-1_Rabbit.svg, A300-661A-M_PHLPP2_Q6ZVD8-1_Rabbit_PDP.jpeg)