Thermo Fisher Scientific PTBP1 Monoclonal Antibody (9A1)

Applications and Tested Dilution

Product Specifications

Target Information

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and influence pre-mRNA processing and other aspects of mRNA metabolism and transport.
While all hnRNPs are present in the nucleus, some shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties.
The protein encoded by this gene has four quasi-RNA recognition motif (RRM) domains that bind RNAs. It binds to intronic polypyrimidine tracts required for pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs.
This protein is localized in the nucleoplasm and detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

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