Thermo Fisher Scientific Mast Cell Chymase Polyclonal Antibody
Rabbit polyclonal antibody targeting human Mast Cell Chymase. Validated for WB and IHC-P applications. Recognizes recombinant fragment (aa 1–218). Suitable for research use in cardiovascular and inflammation studies. Store at 4°C short term or -20°C lo...
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- PA528317
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–218 of Human Mast Cell Chymase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545793 |
Product Specific Information
- Recommended positive control: A549
- Predicted reactivity: Dog (80%), Rhesus Monkey (97%)
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a chymotryptic serine proteinase belonging to the peptidase family S1. It is expressed in mast cells and functions in extracellular matrix degradation, regulation of submucosal gland secretion, and generation of vasoactive peptides. In cardiac and vascular tissues, this protein converts angiotensin I to angiotensin II, influencing blood pressure regulation and cardiovascular pathologies such as hypertension, cardiac hypertrophy, and heart failure. The gene maps to 14q11.2 within a cluster of protease-encoding genes.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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