Thermo Fisher Scientific ACSL5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  GQTECTGGCT FTLPGDWTSG HVGVPLACNY VKLEDVADMN YFTVNNEGEV CIKGTNVFKG YLKDPEKTQE ALDSDGWLHT GDIGRWLPNG TLKIIDRKKN IFKLAQGEYI APEKIENIYN RSQPVLQIFV HGESLRSSLV GVVVPDTDVL PSFAAKLGVK GSFEELCQNQ VVREAILEDL QKIGKESGLK TFEQVKAIFL HPEPFSIENG LLTPTLKAKR GELSKYFRTQ IDSLYEHIQD
• Positive Samples: HL-60, Mouse liver, Rat liver
• Cellular Location: Endoplasmic reticulum, Endoplasmic reticulum membrane, Mitochondrion, Mitochondrion outer membrane, Single-pass type III membrane protein

Target Information

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.