Thermo Fisher Scientific Phospho-CREB (Ser133) Recombinant Rabbit Monoclonal Antibody (CREBS133-4D11), FITC
FITC 형광 표지된 Recombinant Rabbit Monoclonal 항체로, 인간 및 생쥐의 Phospho-CREB (Ser133)을 검출합니다. Flow Cytometry에 적합하며, 고순도 Protein A/G 정제 및 안정적인 PBS-BSA buffer로 제공됩니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific Phospho-CREB (Ser133) Recombinant Rabbit Monoclonal Antibody (CREBS133-4D11), FITC
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | CREBS133-4D11 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Ser133 of human phospho CREB |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897207 |
Additional Formats
- Unconjugated (Cat. MA5-36989)
- APC (Cat. MA5-36992)
- PE (Cat. MA5-36990)
- Custom conjugation available upon request
Target Information
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds to the cyclic AMP response element (CRE) and activates transcription in response to various extracellular signals such as neurotransmitters, hormones, membrane depolarization, and growth factors.
Activation of CREB depends on phosphorylation at serine 133, mediated by MAP kinase pathways (p44/42, p90RSK, p38, MSK1). While CREB can bind DNA regardless of phosphorylation, only the phosphorylated form acts as an active transcription factor.
CREB interacts with CREB binding protein (CBP) at the serine 133 region and is involved in cellular processes including circadian rhythm synchronization, adipocyte differentiation, and learning and memory.
In humans, the CREB gene is located on chromosome 2q. Dysregulation of CREB is associated with Alzheimer’s disease, histiocytoma, and soft tissue melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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