Thermo Fisher Scientific MRGPRX2 Polyclonal Antibody
MRGPRX2 폴리클로날 항체로 인간 MRGPRX2 단백질을 특이적으로 인식합니다. 면역조직화학(IHC-P)에 적합하며, 고순도 Rabbit IgG 폴리클로날 형태입니다. 장기 보관 시 -20°C에서 보관하며, 연구용으로만 사용 가능합니다.
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- PA532931
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Thermo Fisher Scientific MRGPRX2 Polyclonal Antibody
Applications and Tested Dilution
- Immunohistochemistry (Paraffin) [IHC (P)]: 20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 16 amino acid peptide from 3rd extracellular domain of human MRGPRX2 / MRGX2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550392 |
Product Specific Information
- Percent identity with other species by BLAST analysis:
- Human (100%)
- Chimpanzee, Gorilla, Monkey (94%)
- Orangutan (88%)
- Gibbon (81%)
- For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
Orphan receptor probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain.
Cortistatin-14 appears to be a high potency ligand at this receptor and has biological roles in sleep regulation, locomotor activity, and cortical function.
In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.
Expression is limited both peripherally and within the central nervous system, with highest levels in the dorsal root ganglion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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