Thermo Fisher Scientific Phospho-MKP1/MKP2 (Ser296, Ser318) Polyclonal Antibody
MKP1/MKP2 단백질의 Ser296/Ser318 인산화 상태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 액상 형태로 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human DUSP1 (Accession P28562), corresponding to amino acid residues around phosphorylated Ser296. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816327 |
Product Specific Information
This antibody detects endogenous levels of MKP1/2 only when phosphorylated at Serine 296/318.
Target Information
Mitogen-activated protein kinase phosphatases (MKPs) are negative regulators of MAPK activity in mammalian cells.
MKP2 (DUSP4) is a dual threonine/tyrosine phosphatase that specifically dephosphorylates and inactivates MAPKs (ERK, JNK, p38).
It contains one Rhodanese domain and one tyrosine-protein phosphatase domain, is expressed in various tissues, and localized in the nucleus.
Transcription factor E2F-1 regulates MKP2 expression, and the E2F-1/MKP2 pathway mediates apoptosis under oxidative stress.
MKP2 also acts as a transcriptional target of p53, mediating apoptosis via a 10-bp palindrome motif (CTGGCGCCAG) in the MKP2 promoter.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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