Thermo Fisher Scientific SMC6 Polyclonal Antibody
SMC6 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC 및 IHC-P에 사용 가능. 인간 시료에 반응하며 항원 친화 크로마토그래피로 정제됨. 4°C에서 보관하며 연구용으로만 사용.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC-P)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 1050 and the C-terminus (residue 1091) of Human Structural Maintenance of Chromosomes 6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Chimpanzee
Target Information
Core component of the SMC5-SMC6 complex, involved in DNA double-strand break repair via homologous recombination. This complex promotes sister chromatid recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks and is required for telomere maintenance in ALT cell lines. It mediates sumoylation of shelterin complex components, leading to disassembly in ALT-associated PML bodies (APBs). The complex is also required for recruitment of telomeres to PML nuclear bodies and may prevent transcription of episomal DNA such as circular viral genomes. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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