ELK Biotechnology UBE1L rabbit pAb
UBE1L 단백질에 특이적인 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 랫드, 마우스 시료에 반응하며, 세포핵 및 세포질에 위치한 단백질 검출에 적합. 단백질 유비퀴틴화 관련 연구에 활용 가능.
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제품명
UBE1L rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | UBA7; UBE1L; UBE2; Ubiquitin-like modifier-activating enzyme 7; Ubiquitin-activating enzyme 7; D8; Ubiquitin-activating enzyme E1 homolog |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human UBE1L (AA range: 963–1012) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 112 kD |
| Gene ID (Human) | 7318 |
| Human Swiss-Prot No. | P41226 |
| Cellular Localization | Nucleus, nucleoplasm, cytosol |
| Species Reactivity | Human, Rat, Mouse |
Background
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s).
This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARα) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.
[provided by RefSeq, Jul 2008]
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