ELK Biotechnology Tubulin α-3C/D/E rabbit pAb
Human, mouse, rat에서 반응하는 Tubulin α-3C/D/E rabbit polyclonal antibody. WB와 ELISA에 적합하며, microtubule 관련 연구에 활용 가능. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 안정 저장.
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ELK Biotechnology Tubulin α-3C/D/E rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Tubulin α-3C/D/E rabbit pAb |
| Alternative Names | TUBA3C; TUBA2; TUBA3D; Tubulin alpha-3C/D chain; Alpha-tubulin 2; Alpha-tubulin 3C/D; Tubulin alpha-2 chain; TUBA3E; Tubulin alpha-3E chain; Alpha-tubulin 3E |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000; ELISA: 1/5000 (Other applications not yet tested) |
| Immunogen | Synthesized peptide derived from human TUBA3C/E (AA range: 201–250) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| GeneID (Human) | 113457 / 7278 / 112714 |
| Human Swiss-Prot No | Q13748 / Q6PEY2 |
| Cellular Localization | Nucleus, Cytoplasm, Microtubule |
| Species Reactivity | Human; Mouse; Rat |
Background
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta, and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly.
There are multiple alpha and beta tubulin genes, and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% identical to the mouse testis-specific Tuba3 and Tuba7 gene products. It is located in the 13q11 region, which is associated with genetic diseases such as Clouston hidrotic ectodermal dysplasia and Kabuki syndrome.
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