ELK Biotechnology Tropomyosin α rabbit pAb
Tropomyosin α rabbit pAb는 인간, 마우스, 랫트에 반응하는 폴리클로날 항체로, Western blot 및 ELISA에 적합합니다. 세포질 및 세포골격에서 F-actin 스트레스 섬유와 결합하며, 근육 수축 관련 연구에 유용합니다.
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Tropomyosin α rabbit pAb
제품 개요
Tropomyosin α rabbit pAb는 인간 Tropomyosin alpha 유래 합성 펩타이드(AA 40–89)를 면역원으로 제작된 폴리클로날 항체입니다. 세포질 및 세포골격에 위치하며 F-actin 스트레스 섬유와 결합합니다. 근육 수축 조절 및 세포골격 안정성 연구에 활용할 수 있습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Tropomyosin α rabbit pAb |
| Alternative Names | TPM1; C15orf13; TMSA; Tropomyosin alpha-1 chain; Alpha-tropomyosin; Tropomyosin-1 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Tropomyosin alpha (AA range: 40–89) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 35 kDa |
| Gene ID (Human) | 7168 |
| Human Swiss-Prot No. | P09493 |
| Cellular Localization | Cytoplasm, cytoskeleton. Associates with F-actin stress fibers. |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin consists of two alpha-helical chains arranged as a coiled-coil, polymerized end to end along actin filaments to provide stability. The encoded protein forms the predominant tropomyosin of striated muscle and interacts with the troponin complex to regulate calcium-dependent actin-myosin interaction during muscle contraction. In smooth muscle and non-muscle cells, multiple alternatively spliced isoforms are described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.
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