ELK Biotechnology TGFβ RII rabbit pAb
TGFβ RII rabbit pAb는 인간, 마우스, 랫트 시료에 반응하는 폴리클로날 항체입니다. IF, WB, IHC, ELISA 등 다양한 응용에 사용 가능하며, 인간 TGFβ Receptor II 유래 펩타이드로 면역화되었습니다. 세포막 단백질 검출에 적합하고 -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology TGFβ RII rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | TGFβ RII rabbit pAb |
| Alternative Names | TGFBR2; TGF-beta receptor type-2; TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II |
| Applications | IF; WB; IHC; ELISA |
| Recommended Dilutions | IF: 1:50–200 Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human TGF beta Receptor II (AA range: 91–140) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 65 kD |
| GeneID (Human) | 7048 |
| Human Swiss-Prot No | P37173 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Membrane raft; [Isoform 3]: Secreted |
Background
This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. (provided by RefSeq, Jul 2008)
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