ELK Biotechnology TRAIL rabbit pAb
TRAIL rabbit pAb는 인간, 랫트, 마우스에 반응하는 폴리클로날 항체로, TNFSF10 단백질을 인식합니다. WB, IHC, IF, ELISA에 적합하며, 종양세포의 세포사멸 연구에 활용됩니다. 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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제품명
TRAIL rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TNFSF10; APO2L; TRAIL; Tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; Apo-2L; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD antigen CD253 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TNFSF10 (AA range: 31–80) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 30 kDa |
| Gene ID (Human) | 8743 |
| Human Swiss-Prot No | P50591 |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein; Secreted; Exists both as membrane-bound and soluble form |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells, although it is expressed at significant levels in most normal tissues. This protein binds to several members of the TNF receptor superfamily, including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly TNFRSF11B/OPG. Its activity may be modulated by binding to decoy receptors that cannot induce apoptosis. Binding to its receptors triggers activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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