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ELK Biotechnology TP53INP1 rabbit pAb
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TP53INP1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 사람, 쥐, 랫드 시료에 반응하며, 세포 스트레스에 따른 핵-세포질 이동 연구에 활용 가능합니다. -20°C에서 1년 보관 가능합니다.
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ELK Biotechnology ES3629-100UL TP53INP1 rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES3629-50UL TP53INP1 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology TP53INP1 rabbit pAb
TP53INP1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | TP53INP1 rabbit pAb |
| Alternative Names | TP53INP1; P53DINP1; SIP; Tumor protein p53-inducible nuclear protein 1; Stress-induced protein; p53-dependent damage-inducible nuclear protein 1; p53DINP1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/40000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TP53INP1. AA range: 171-220 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 27 kD |
| Gene ID (Human) | 94241 |
| Human Swiss-Prot No. | Q96A56 |
| Cellular Localization | Cytoplasm, cytosol, nucleus, PML body, cytoplasmic vesicle (autophagosome). Shuttles between the nucleus and cytoplasm depending on cellular stress, and re-localizes to autophagosomes upon autophagy activation. |
| Species Reactivity | Human; Rat; Mouse |
Background
In response to double-strand DNA breaks, TP53INP1 promotes p53/TP53 phosphorylation on Ser-46 and subsequent apoptosis. It is induced by adriamycin, gamma irradiation, and H₂O₂ in a p53-dependent manner, and at lower levels by UV irradiation.
Subcellular location: concentrated in PML/POD/ND10 nuclear bodies.
Subunit: interacts with TP53 and HIPK2.
Tissue specificity: ubiquitously expressed.
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