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ELK Biotechnology TNF-IP 8 rabbit pAb
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TNF-IP 8 rabbit pAb는 인간 TNFAIP8 단백질을 인식하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 세포질에 위치한 단백질 검출에 사용되며, 종양 진행 및 세포 사멸 억제 연구에 유용합니다.
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ELK Biotechnology ES3621-100UL TNF-IP 8 rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES3621-50UL TNF-IP 8 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology TNF-IP 8 rabbit pAb
제품명
TNF-IP 8 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TNFAIP8; Tumor necrosis factor alpha-induced protein 8; TNF alpha-induced protein 8; Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; TNF-induced protein GG2-1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TFIP8 (AA range: 31–80) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 23 kDa |
| Gene ID (Human) | 25816 |
| Human Swiss-Prot No | O95379 |
| Cellular Localization | Cytoplasm |
| Species Reactivity | Human; Mouse |
Background
- Developmental stage: Expressed at high levels in fetal liver, lung, and kidney.
- Function: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses TNF-mediated apoptosis by inhibiting caspase-8 activity, resulting in inhibition of BID cleavage and caspase-3 activation.
- Induction: By nuclear factor-KB (NF-KB) and TNF. TNF induction depends on NF-KB activation.
- Similarity: Belongs to the TNFAIP8 family.
- Tissue specificity: Expressed at high levels in spleen, lymph node, thymus, thyroid, bone marrow, and placenta. Also highly expressed in various tumor tissues and cytokine-activated cultured cells. Low expression in spinal cord, ovary, lung, adrenal glands, heart, brain, testis, and skeletal muscle.
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