ELK Biotechnology TCF-3 rabbit pAb
TCF-3 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫트에 반응하며 핵에 위치한 단백질 검출에 적합. 림프구 발달 및 백혈병 관련 연구에 유용.
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제품명
TCF-3 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TCF3; BHLHB21; E2A; ITF1; Transcription factor E2-alpha; Class B basic helix-loop-helix protein 21; bHLHb21; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human TCF3 (AA range: 571–620) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 68 kDa |
| Gene ID (Human) | 6929 |
| Human Swiss-Prot No. | P15923 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins.
E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies.
This gene is also involved in several chromosomal translocations associated with lymphoid malignancies, including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT), and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been identified.
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