ELK Biotechnology TBX1 rabbit pAb
TBX1 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간, 생쥐, 흰쥐 시료에 반응하며 핵에 주로 발현. DiGeorge 증후군 관련 연구 및 발달 유전자 조절 연구에 적합.
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제품명
TBX1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TBX1; T-box transcription factor TBX1; T-box protein 1; Testis-specific T-box protein |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human TBX1. AA range: 311-360 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 43 kD |
| Gene ID (Human) | 6899 |
| Human Swiss-Prot No. | O43435 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box.
T-box genes encode transcription factors involved in the regulation of developmental processes.
This gene product shares 98% amino acid sequence identity with the mouse ortholog.
DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped.
Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS.
Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
[provided by RefSeq, Jul 2008]
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