ELK Biotechnology Syntaxin 1 rabbit pAb
Syntaxin 1 rabbit pAb는 신경계 특이 단백질 Syntaxin-1A를 인식하는 고품질 폴리클로날 항체입니다. WB, IHC, IF, ELISA 등 다양한 응용에 적합하며, 인간·마우스·랫·원숭이 시료에 반응합니다. 세포막 및 시냅스 소포 위치 연구에 유용합니다.
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Syntaxin 1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | Syntaxin 1 rabbit pAb |
| Alternative Names | STX1A; STX1; Syntaxin-1A; Neuron-specific antigen HPC-1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Syntaxin 1A (AA range: 1–50) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 35 kD |
| GeneID (Human) | 6804 |
| Human Swiss-Prot No. | Q16623 |
| Cellular Localization | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein; Cell junction, synapse, synaptosome; Cell membrane; Colocalizes with KCNB1 at the cell membrane; Isoform 2: Secreted |
| Species Reactivity | Human; Mouse; Rat; Monkey |
Background
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. They possess a single C-terminal transmembrane domain, a SNARE (Soluble NSF Attachment Protein Receptor) domain known as H3, and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent manner and interact with voltage-dependent calcium and potassium channels via the C-terminal H3 domain. This gene product plays a key role in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been identified.
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