ELK Biotechnology Splicing factor 1 rabbit pAb
인간 SF1 유래 항원으로 제작된 rabbit polyclonal antibody. WB, IHC, IF, ELISA 등에 사용 가능. 핵 내 스플라이싱 인자 검출에 적합하며 높은 특이성과 안정성 제공. -20°C에서 1년 보관 가능.
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Splicing factor 1 rabbit pAb
공급업체: ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Splicing factor 1 rabbit pAb |
| Alternative Names | SF1; ZFM1; ZNF162; Splicing factor 1; Mammalian branch point-binding protein; BBP; mBBP; Transcription factor ZFM1; Zinc finger gene in MEN1 locus; Zinc finger protein 162 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human SF1 (AA range: 48–97) |
| Species Reactivity | Human; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 68 kD |
| GeneID (Human) | 7536 |
| Human Swiss-Prot No | Q15637 |
| Cellular Localization | Nucleus |
| Storage | -20°C / 1 year |
| Host | Rabbit |
Background
This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3′ splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
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