ELK Biotechnology SNX1 rabbit pAb
SNX1 rabbit pAb는 인간 SNX1 단백질을 인식하는 폴리클로날 항체로, WB, ELISA, IHC에 적합합니다. 세포 내 엔도솜 및 골지막에 위치한 SNX1 단백질 연구에 활용되며, 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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제품명
SNX1 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SNX1; Sorting nexin-1 |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | Synthesized peptide derived from the internal region of human SNX1 |
| Species Reactivity | Human; Mouse; Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kD |
| GeneID (Human) | 6642 |
| Human Swiss-Prot No | Q13596 |
| Storage | -20°C / 1 year |
세포 내 위치 (Cellular Localization)
Endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side.
Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Cell projection, lamellipodium.
Enriched on tubular elements of the early endosome membrane.
Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:15498486).
Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs), which are budding from early endosome vacuoles before maturing into late endosome vacuoles (PubMed:18088323).
Colocalizes with DNAJC13 and Shigella dysenteriae toxin stx.
배경 정보 (Background)
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking.
This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor.
It also plays a role in sorting protease-activated receptor-1 from early endosomes to lysosomes.
This protein may form oligomeric complexes with family members.
This gene results in three transcript variants encoding distinct isoforms.
[provided by RefSeq, Jul 2008]
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