ELK Biotechnology SIRT1 rabbit pAb
SIRT1 단백질을 인식하는 토끼 다클론 항체로, IF, WB, IHC, ELISA 등에 사용 가능. 인간 SirT1 유래 펩타이드로 면역화. 핵 및 세포질에서 발현되는 SIRT1 단백질 검출에 적합. -20°C에서 1년 보관 가능.
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제품명
SIRT1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | SIRT1; SIR2L1; NAD-dependent protein deacetylase sirtuin-1; hSIRT1; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2 |
| Applications | IF; WB; IHC; ELISA |
| Recommended Dilutions | IF: 1:50–200 WB: 1:500–1:2000 IHC: 1:100–1:300 ELISA: 1:5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human SirT1 (AA range: 13–62) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 85–110 kDa |
| Gene ID (Human) | 23411 |
| Human Swiss-Prot No. | Q96EB6 |
| Species Reactivity | Human; Mouse |
세포 내 위치
Nucleus, PML body, Cytoplasm. Recruited to nuclear bodies via interaction with PML (PubMed:12006491).
Colocalized with APEX1 in the nucleus (PubMed:19934257).
May be found in nucleolus, nuclear euchromatin, heterochromatin, and inner membrane (PubMed:15469825).
Shuttles between nucleus and cytoplasm (By similarity).
Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178).
SirtT1 75 kDa fragment: Cytoplasm, Mitochondrion.
Background
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of this family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been fully determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene belongs to class I of the sirtuin family. Alternative splicing results in multiple transcript variants. (RefSeq, Dec 2008)
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