ELK Biotechnology SERCA1 rabbit pAb
SERCA1 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 사용 가능. 인간 ATP2A1 유래 합성 펩타이드로 면역화. 근육세포 내 칼슘 펌프 연구에 적합하며, 다양한 종에 반응. -20°C에서 1년 보관 가능.
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제품명
SERCA1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ATP2A1; Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA1; SR Ca(2+)-ATPase 1; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type; fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human ATP2A1 (AA range: 548-597) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 100 kDa |
| Gene ID (Human) | 487 |
| Human Swiss-Prot No. | O14983 |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein. |
| Species Reactivity | Human; Mouse; Rat; Salamander; Pig |
Background
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms.
[provided by RefSeq, Oct 2013]
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