ELK Biotechnology Septin 7 rabbit pAb
Human SEPT7 유래 펩타이드로 제작된 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 사용 가능하며 48kDa 밴드 검출. 세포질 및 방추체 관련 단백질 연구에 적합. -20°C에서 1년 보관 가능.
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ELK Biotechnology Septin 7 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Septin 7 rabbit pAb |
| Alternative Names | SEPT7; CDC10; Septin-7; CDC10 protein homolog |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000, IHC-p: 1/50–1/300, ELISA: 1/20000. Not yet tested in other applications. |
| Immunogen | Antiserum produced against synthesized peptide derived from human SEPT7 (AA range: 350–399) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 48 kDa |
| GeneID (Human) | 989 |
| Human Swiss-Prot No | Q16181 |
| Cellular Localization | Cytoplasm; Chromosome (centromere, kinetochore); Cytoskeleton (spindle); Cleavage furrow; Midbody; Cilium axoneme; Flagellum. Distributed throughout the cytoplasm in prometaphase cells, associated with spindle during metaphase, and with central spindle and cleavage furrow in anaphase. Detected at midbody in telophase. Associated with actin stress fibers and found in the sperm annulus. |
| Species Reactivity | Human; Mouse; Rat |
Background
septin 7 (SEPT7), Homo sapiens
This gene encodes a protein highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein shares similarity with Diff 6 of Drosophila and H5 of mouse. Each of these proteins, including yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament inside the cytoplasmic membrane and is essential for cytokinesis.
Human SEPT7 functions in gliomagenesis and suppression of glioma cell growth, and is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17, and 19.
(Information provided by RefSeq, Jul 2011)
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