Thermo Fisher Scientific Phospho-Cofilin (Ser3) Polyclonal Antibody
Phospho-Cofilin (Ser3) 인산화 단백질 검출용 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 적합하며, actin cytos켈레톤 조절 연구에 활용. 고순도 항원 친화 크로마토그래피 정제, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunocytochemistry (ICC/IF) | 1:250 | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human cofilin that contains serine 3. The sequence is conserved in mouse and rat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533565 |
Target Information
Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. It regulates actin cytoskeleton dynamics and is important for normal progress through mitosis and cytokinesis. Cofilin plays a role in regulating cell morphology and cytoskeletal organization, and is required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartments to the cell membrane, enhancing chemokine uptake and degradation. It is also essential for neural tube morphogenesis and neural crest cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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