Thermo Fisher Scientific P-Cadherin (CDH3) Monoclonal Antibody (12H6)
인간 P-Cadherin(CDH3)을 특이적으로 인식하는 Mouse IgG1 단클론 항체. Western blot, ICC/IF, Flow cytometry에 적합. 단백질 A/G로 정제된 액상 형태로 제공되며, PBS(pH 7.4)에 보존제 없이 -20°C 보관. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 12H6 |
| Immunogen | Recombinant human P-cadherin fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein belonging to the cadherin superfamily. These calcium-dependent cell-cell adhesion glycoproteins play key roles in development, wound healing, cell signaling, growth, and differentiation.
P-cadherin is expressed in human fetal tissues and adult structures such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. It is also found in embryonic stem cells and normal mammary and hair follicle stem cells. Overexpression of P-cadherin has been linked to poor prognosis in several carcinomas, including breast, prostate, ovary, colon, and stomach. Mutations in CDH3 are associated with congenital hypotrichosis with juvenile macular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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