Thermo Fisher Scientific Phospho-NMDAR2B (Tyr1070) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Product Specifications

Product Specific Information

This antibody detects endogenous levels of NMDAR2B only when phosphorylated at Tyr1070.

Target Information

NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) are involved in long-term potentiation, an activity-dependent increase in synaptic transmission efficiency related to memory and learning.
NMDARs play a critical role in neuronal development and are implicated in central nervous system disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death.
Overexpression of the NR2B subunit enhances learning and memory, while reduced NR2B expression is associated with age-related memory impairment.
Phosphorylation of Tyr1472 on NR2B may increase NMDAR expression at the synapse, contributing to synaptic plasticity.
NMDAR2B forms a heterotrimer with NR1, NR2, and NR3 subunits.
Dysfunction of NMDAR2B is associated with epileptic encephalopathy and autosomal dominant 6-related intellectual disability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.