Thermo Fisher Scientific SETD8 Recombinant Rabbit Monoclonal Antibody (ARC0916)
SETD8 단백질을 인식하는 재조합 토끼 단클론 항체. Western blot과 ELISA에 적합하며, 인간 및 생쥐 시료에 반응. 고순도 친화 크로마토그래피 정제 및 안정한 PBS/glycerol buffer 포뮬레이션. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA (ELISA) | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0916 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–100 of human KMT5A/SETD8 (Q9NQR1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.67 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849348 |
Product Specific Information
Immunogen sequence:
MGEGGAAAAL VAAAAAAAAA AAAVVAGQRR RRLGRRARCH GPGRAAGGKM SKPCAVEAAA AAVAATAPGP EMVERRGPGR PRTDGENVFT GQSKIYSYMS
Target Information
SETD8 is a histone methyltransferase that specifically monomethylates Lys-20 of histone H4.
H4 Lys-20 monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression.
The protein mainly functions in euchromatin regions, playing a central role in silencing euchromatic genes.
It is required for cell proliferation, contributing to the maintenance of proper higher-order DNA structure during mitosis.
SETD8 is also involved in chromosome condensation and proper cytokinesis.
Nucleosomes are preferred as substrates compared to free histones.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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