Thermo Fisher Scientific IL31RA Polyclonal Antibody
IL31RA 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체로, WB, ICC/IF, Flow Cytometry 등에 사용 가능. 인간 시료 반응성, 항원 친화 크로마토그래피 정제, 동결건조 형태로 제공. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–15 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg per million cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human IL-31 RA (Ala20–Ser516) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606511 |
Product Specific Information
- In direct ELISAs, approximately 5% cross-reactivity with recombinant mouse IL-31 RA is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
IL-31 is a T cell cytokine preferentially produced by T helper type 2 cells. It signals through a heterodimeric receptor composed of IL-31 receptor (IL-31R) and oncostatin M receptor (OSM). This receptor complex activates JAK1, JAK2, Stat1, Stat3, Stat5, and PI3K/AKT pathways, while SHP-2 and Shc adapter molecules contribute to MAP kinase activation.
Overexpression of IL-31 in mice causes pruritus and dermatitis resembling human atopic dermatitis (AD). In AD patients, IL-31R expression is elevated on epidermal keratinocytes, and infiltrating cells express IL-31 mRNA. IL-31 is implicated in itch sensation and scratching behavior, suggesting potential as a target for antipruritic drug development.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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