Thermo Fisher Scientific IFN alpha Monoclonal Antibody (EBI-10), FITC, eBioscience

Applications

Tested Dilution

Publications

ELISA (ELISA)

Assay-Dependent

-

Product Specifications

Host/Isotype

Mouse / IgG

Class

Monoclonal

Type

Antibody

Clone

EBI-10

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Concentration

0.1 mg/mL

Storage conditions

4° C, store in dark

Shipping conditions

Wet ice

RRID

AB_10609217

Product Specific Information

Description: Anti-Human IFN-alpha (EBI-10) inhibits the antiviral activity of interferon alpha. EBI-10 (IgG), was previously shown tob e quite specific for IFN-alpha2; whereas this antibody was able to inhibit the antiviral activity of recombinant IFN alpha2 at concentrations below 1 µg/mL (Biochem. J. 1991 276).

Applications Tested: Flow Cytometry.

Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser

Target Information

IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.