Thermo Fisher Scientific SCN2A (NaV1.2) Polyclonal Antibody

Thermo Fisher Scientific SCN2A (NaV1.2) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW) depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and store at -20°C.
Avoid repeated freeze-thaw cycles. Centrifuge all antibody preparations before use (10000 × g for 5 min).

Target Information

Voltage-gated sodium channels are selective ion channels that regulate sodium ion permeability in excitable cells. During action potential propagation, sodium channels allow sodium influx, rapidly depolarizing the cell.
Type I and III alpha subunits are mainly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are abundant along axons.
The beta1 subunit of sodium channel type I is expressed in brain, skeletal, and cardiac muscle. In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also found in pyramidal cells of the deep cerebellar nuclei.
Impaired voltage-gated sodium channels are associated with disorders such as myotonia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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