Thermo Fisher Scientific PKD1/2/3/PKC mu Polyclonal Antibody
Rabbit polyclonal antibody recognizing PKD1/2/3/PKC mu. Validated for Western blot (1:1,000). Predicted to react with mouse and rat. Involved in studies of signal transduction, cell survival, and Golgi trafficking. Supplied as liquid, 1 mg/mL, for rese...
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human PRKD1/PRKD2/PRKD10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2691716 |
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC. Involved in regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, and cell survival through NF-kappa-B activation. Plays roles in cell migration, differentiation (via HDAC7 nuclear export), and proliferation (via MAPK1/3 signaling). Also implicated in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis, and inflammatory response.
Phosphorylates EGFR on dual threonine residues, suppressing EGF-induced MAPK8/JNK1 activation. Phosphorylates RIN1, promoting binding to 14-3-3 proteins (YWHAB, YWHAE, YWHAZ) and competing with RAF1 for Ras binding. Acts downstream of G-protein beta/gamma-subunit complex to maintain Golgi integrity and regulate vesicle fission in the trans-Golgi network (TGN).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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