Thermo Fisher Scientific TRAF1 Polyclonal Antibody
TRAF1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot 및 IHC(P)에서 사용 가능하며, Human에 반응합니다. 고순도 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PA527689
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–228 of Human TRAF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.87 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545165 |
Product Specific Information
- Recommended positive controls: Raji
- Predicted reactivity: Rhesus Monkey (94%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is a member of the TNF receptor (TNFR)-associated factor (TRAF) protein family. TRAF proteins mediate signal transduction from various receptors of the TNFR superfamily.
TRAF1 and TRAF2 form a heterodimeric complex required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. This complex also interacts with inhibitor-of-apoptosis proteins (IAPs), mediating anti-apoptotic signals from TNF receptors.
Expression of TRAF1 can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) interacts with TRAF1 and other TRAF proteins, linking LMP1-mediated B lymphocyte transformation to TNFR signal transduction.
Three transcript variants encoding two different isoforms have been identified for this gene.
주의사항
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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