Thermo Fisher Scientific PDI Monoclonal Antibody (2F6G12H2)

Applications and Tested Dilution

Immunohistochemistry (Paraffin) (IHC (P))

• Dilution: 1:20–1:80

ELISA

• Dilution: 1:1,000–1:2,000

Product Specifications

Product Specific Information

• Specificity: Human P4HB/ERBA2L

Target Information

Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage, and rearrangement of disulfide bonds. At the cell surface, it acts as a reductase that cleaves disulfide bonds of proteins attached to the cell, potentially causing structural modifications of exofacial proteins. Inside the cell, PDI forms or rearranges disulfide bonds of nascent proteins. At high concentrations, it functions as a chaperone that inhibits aggregation of misfolded proteins, while at low concentrations, it facilitates aggregation (anti-chaperone activity). PDI may cooperate with other chaperones in the structural modification of TG precursor in hormone biogenesis. It also acts as a structural subunit of enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein (MTTP). PDI serves as a receptor for LGALS9, retaining P4HB at the cell surface of Th2 T helper cells, enhancing disulfide reductase activity at the plasma membrane, altering the redox state, and promoting cell migration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.