Thermo Fisher Scientific HSC70 Polyclonal Antibody
Thermo Fisher Scientific의 HSC70 Polyclonal Antibody는 인간 HSPA8 단백질(aa 1-300)에 대응하는 항원을 기반으로 제작된 Rabbit IgG 폴리클로날 항체입니다. Western blot 및 Immunocytochemistry에 적합하며, 세포막·핵·세포질 등 다양한 위치에서 발현되는 HSC70 단백질 검출에 활용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–300 of human HSPA8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.08 mg/mL |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805658 |
Product Specific Information
Immunogen sequence:
MSKGPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA MNPTNTVFDA KRLIGRRFDD AVVQSDMKHW PFMVVNDAGR PKVQVEYKGE TKSFYPEEVS SMVLTKMKEI AEAYLGKTVT NAVVTVPAYF NDSQRQATKD AGTIAGLNVL RIINEPTAAA IAYGLDKKVG AERNVLIFDL GGGTFDVSIL TIEDGIFEVK STAGDTHLGG EDFDNRMVNH FIAEFKRKHK KDISENKRAV RRLRTACERA KRTLSSSTQA SIEIDSLYEG IDFYTSITRA
Positive Samples:
U-937, U-87MG, Raji, A-549, HeLa, Jurkat, MCF-7
Cellular Location:
Cell membrane, Cytoplasm, Melanosome, Nucleus, Nucleolus
Target Information
The HSP70 family comprises highly conserved proteins induced by various biological stresses, including heat stress, across all examined organisms.
Human HSP70 family members include:
- HSP70: Strongly inducible and constitutively expressed in primate cells
- HSP72: Induced exclusively under stress conditions
- HSC70 (Cognate protein): 72 kDa, constitutively expressed, involved in uncoating clathrin-coated vesicles
- GRP78 (BiP): 78 kDa, localized in the endoplasmic reticulum
- HSP75 (p75): 75 kDa, mitochondrial protein
HSC70 (also known as HSC71, HSC73, HSP73, p72, prp73) is constitutively expressed and slightly heat-inducible. It binds to clathrin light chains for vesicle uncoating and interacts with the cytoskeleton to facilitate rearrangements. Additionally, HSC70 promotes lysosomal degradation of intracellular proteins and modulates aggregation and folding of mitochondrial precursor proteins in vitro.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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