Thermo Fisher Scientific IFI16 Polyclonal Antibody
Thermo Fisher Scientific의 IFI16 Polyclonal Antibody는 Mouse, Rat, Human에서 반응하며 Western blot, IHC, ELISA에 사용 가능. Rabbit IgG 기반의 비결합 항체로, 세포 내 IFI16 단백질 검출에 적합. Affinity Chromatography로 정제된 고순도 항체.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–300 of human IFI16 (NP_0013517961) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.72 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805659 |
Product Specific Information
Immunogen sequence:
MGKKYKNIVL LKGLEVINDY HFRMVKSLLS NDLKLNLKMR EEYDKIQIAD LMEEKFRGDA GLGKLIKIFE DIPTLEDLAE TLKKEKLKVK GPALSRKRKK EVDATSPAPS TSSTVKTEGA EATPGAQKRK KSTKEKAGPK GSKVSEEQTQ PPSPAGAGMS TAMGRSPSPK TSLSAPPNSS STENPKTVAK CQVTPRRNVL QKRPVIVKVL STTKPFEYET PEMEKKIMFH ATVATQTQFF HVKVLNTSLK EKFNGKKIII ISDYLEYDSL LEVNEESTVS EAGPNQTFEV PNKIINRAKE
Positive Samples: Mouse spleen, Mouse lung
Cellular Location: Cytoplasm, Nucleus
Target Information
IFI16 (gamma-interferon-inducible protein 16) binds double-stranded DNA, preferentially to supercoiled and cruciform DNA structures. It is involved in transcriptional regulation and acts as a transcriptional repressor. IFI16 may regulate hematopoietic differentiation and cell proliferation through modulation of p53/TP53 and retinoblastoma protein functions. Additionally, IFI16 participates in innate immune responses by recognizing viral dsDNA in the cytosol and nucleus, recruiting TMEM173/STING, and inducing IFN-beta production. It is essential for activating the IFR3 signaling cascade during HSV-1 infection and contributes to heterochromatin assembly on viral DNA, inhibiting viral gene expression and replication. IFI16 also plays a role in MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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