Thermo Fisher Scientific Factor VIII Polyclonal Antibody

Thermo Fisher Scientific Factor VIII Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:1,000
• Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200

Product Specifications

Product Specific Information

Purity is >95% by SDS-PAGE.

Target Information

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation. Factor VIII acts as a cofactor for factor IXa, converting factor X to its active form Xa in the presence of Ca²⁺ and phospholipids.
Two alternatively spliced transcripts are produced:

1. Transcript variant 1: Encodes a large glycoprotein (isoform a), circulating in plasma and associating with von Willebrand factor in a noncovalent complex.
2. Transcript variant 2: Encodes a smaller protein (isoform b) containing primarily the phospholipid-binding domain essential for coagulant activity.

Defects in this gene cause hemophilia A, a common recessive X-linked coagulation disorder.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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