Thermo Fisher Scientific ASIC1 Polyclonal Antibody
Guinea pig 유래 ASIC1 폴리클로날 항체로, rat ASIC beta의 합성 펩타이드(3-18 aa)에 대응합니다. IHC(F)에서 1:1,000 희석으로 검증되었으며, 양성 대조군으로 척수 조직이 권장됩니다. 단기 4°C, 장기 -20°C 보관을 권장합니다.
- 카탈로그번호
- PA124648
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Guinea pig / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues A(3) G S E L D E G D D S P R D L V(18) of rat ASIC beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_779137 |
Product Specific Information
- Recommended positive controls: Spinal cord.
Target Information
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of this family are amiloride-sensitive sodium channels with intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop containing many cysteine residues with conserved spacing.
The encoded protein is expressed in most brain neurons and may function as an ion channel subunit. It is a cation channel with high affinity for sodium, gated by extracellular protons and inhibited by the diuretic amiloride.
ASIC1 is permeable to Ca²⁺, Li⁺, and K⁺ and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, neocortical and allocortical regions, dentate granule cells, hippocampal CA1–CA3 pyramidal cells, habenula, basolateral amygdaloid nuclei, and cerebellar Purkinje and granule cells. It is also diffusely detected across basal ganglia regions including thalamic nuclei, substantia nigra, striatum, globus pallidus, hypothalamus, midbrain, pons, medulla, and choroid plexus.
Isoform 3 is expressed only in dorsal root ganglia, while isoform 1 is expressed in DRG, spinal cord, trigeminal ganglia, and trigeminal mesencephalic nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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