Thermo Fisher Scientific COX11 Polyclonal Antibody
COX11 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 Immunocytochemistry에 적합합니다. 인간과 마우스 시료에 반응하며, 고순도 Affinity chromatography 정제 제품입니다. PBS 버퍼와 글리세롤로 안정화되어 -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human COX11 (Accession Q9Y6N1), corresponding to amino acid residues S60–S110 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850742 |
Product Specific Information
This antibody detects endogenous levels of total COX11.
Target Information
Cytochrome c oxidase (COX) is the terminal enzyme in the electron transfer chain, functioning as a transmembrane proton pump that builds an electrochemical gradient using the chemical energy from the reduction of O₂.
Cytochrome c oxidase assembly protein COX11 is a mitochondrial membrane protein essential for the construction of an active COX complex. It contains a single transmembrane helix downstream of the N-terminal mitochondrial targeting sequence and a C-terminal Cu(I)-binding domain.
COX assembly requires the delivery of metal cofactors, and COX11, along with COX12 and SCO1/2, acts as a metal ion chaperone necessary for copper insertion into CuA and CuB redox-active copper centers of COX in eukaryotes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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