Thermo Fisher Scientific CYP1A1/CYP1A2 Polyclonal Antibody

Thermo Fisher Scientific CYP1A1/CYP1A2 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:1,000
• Immunocytochemistry (ICC/IF): 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total Cytochrome P450 1A1/2.

Target Information

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme’s endogenous substrate is unknown; however, it can metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3′ untranslated region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.