Thermo Fisher Scientific Adiponectin Receptor 2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunogen sequence: FPGKCDIWFH SHQLFHIFVV AGAFVHFHGV SNLQEFRFMI GGGCSEEDAL
• For short-term use, store at 2–8°C up to 1 week.
• For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted homology:
  Cow: 93%, Dog: 93%, Goat: 92%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%

Target Information

Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance, and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin is mediated by increased fatty-acid oxidation through activation of AMP kinase and PPAR.
Adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) were identified by expression cloning. AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. These receptors are predicted to contain seven transmembrane domains but are structurally and functionally distinct from G-protein-coupled receptors. Expression or suppression of AdipoR1/R2 supports their role as receptors for globular and full-length adiponectin, mediating increased AMP kinase and PPAR- ligand activities, fatty-acid oxidation, and glucose uptake.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.