Thermo Fisher Scientific Synaptotagmin 1 Polyclonal Antibody
Goat polyclonal antibody against Synaptotagmin 1 for WB and IHC applications. Recognizes human and predicted to react with multiple species. Supplied as liquid, unconjugated, 0.5 mg/mL concentration in TBS buffer with BSA and sodium azide. For research...
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Applications
Western Blot (WB)
- Tested Dilution: 0.3–1 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 4–6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (RDLQSAEKEEQEK) corresponding to internal amino acids of SYT1 (aa 261–274) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10982413 |
Product Specific Information
- Predicted to react with bovine, canine, mouse, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 1:2000.
Target Information
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein widely expressed throughout the CNS. It acts as a Ca²⁺ sensor regulating exocytosis and neurotransmitter release. Ca²⁺-mediated binding of SNAP25 by Synaptotagmin 1 is essential for membrane fusion. Specific residues within the C2B domain determine endocytic rate and vesicle size. Synaptotagmin 1 also interacts with acidic phospholipids, neurexins, syntaxin, and AP2. Dysfunction is associated with food-borne and infant botulism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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